FA355 Heritage American (@FA355)

ACE2 Theory may be wrong? Confronting the COVID-19 Pandemic with Systems Biology "Methods: Using a Systems Biology approach, we have integrated genomic, transcriptomic, proteomic, and molecular evolution data layers to understand its impact on host cells. We overlay these analyses with high-resolution structural models and atomistic molecular dynamics simulations conducted on the Summit supercomputer at the Oak Ridge National Laboratory. Findings: Transcriptomic and proteomic data indicate little to no expression of ACE2 in lung tissue." "Our structural analysis of the SARS-CoV-2 proteome suggests involvement of the highly conserved nsp5 protein as part of a major mechanism that suppresses the nuclear factor transcription factor kappa B (NF-κB) pathway, eliminating the host cell's interferon-based antiviral response." https://www.biorxiv.org/content/10.1101/2020.04.06.028712v1