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Discovery of Ivermectin Merck & Co., Inc. American Chemical Society Discovery of Ivermectin A National Historic Chemical Landmark The American Chemical Society designated the discovery of ivermectin as a National Historic Chemical Landmark in a ceremony at Merck & Co., Inc., in Kenilworth, New Jersey, on 2 December 2016. The commemorative plaque reads The synthesis and development of ivermectin by Merck in the 1970s and 1980s provided a breakthrough treatment against infectious diseases transmitted by parasites. This discovery resulted from an international collaboration that screened hundreds of natural products to identify a promising lead compound. Merck scientists synthesized thousands of analogs of this lead and tested them. The result, ivermectin, offered a highly effective treatment for several parasitic diseases affecting a variety of animals. Following its approval for human use in 1987, Merck established a worldwide program to donate ivermectin as Mectizan® to treat onchocerciasis (river blindness), greatly reducing the prevalence of this debilitating disease. In 2015, Merck scientist William Campbell shared the Nobel Prize in Physiology or Medicine for his role in developing ivermectin https://www.acs.org/content/dam/acsorg/education/whatischemistry/landmarks/discovery-of-ivermectin-mectizan.pdf