ValerieCurren (@ValerieCurren)

Gail Combs dives DEEP... https://www.theqtree.com/2022/02/11/dear-kag-20220211-the-pub-is-open-g-bay-gab-marketplace-is-here-fake-science-normalized-by-fake-news-and-fake-entertainment-malone-and-bhakdi-validated-by-pro-vax-paper/comment-page-1/#comment-868217 Gail Combs Gail CombsOnline Coyote February 11, 2022 06:44 My curiosity bump asks — WHAT ARE GERMINAL CENTERS? ……….. Germinal Center – an overview | ScienceDirect Topics https://www.sciencedirect.com/topics/immunology-and-microbiology/germinal-center Duck Duck Go blurb: Germinal centers have a dark and light zone surrounded by the mantle zone (see germinal center in the tonsil, Figure 3-16 ). They can form in the lymph node follicles and they are a site where B cells become activated, proliferate, switch Ig class, and increase affinity for the antigen by somatic hypermutation. This is an informative article and contains EXCERPTS from several books. I post two. Starting with the definition I was looking for: Germinal Center The germinal center (GC) is a specialized microstructure that forms in secondary lymphoid tissues, where mature B cells proliferate, differentiate, and mutate their antibody genes. From: Reference Module in Biomedical Sciences, 2021 https://www.sciencedirect.com/science/article/pii/B9780128187319001853 OK, so that is WHY Dr Malone found this paper so important. The First Excerpt From a book: Lymph nodes and extranodal lymphoid tissue, spleen and thymus Simon S. Cross MD FRCPath, in Underwood’s Pathology, 2019 Peripheral T-cell lymphoma Lymphomas of postthymic (‘peripheral’) T cells https://www.sciencedirect.com/topics/medicine-and-dentistry/t-cell are relatively uncommon in Europe and America, contributing no more than 10% of NHL cases. In the Far East and Caribbean, they are much more common, with the increased prevalence largely due to an endemic retrovirus, https://www.sciencedirect.com/topics/medicine-and-dentistry/retroviridae human T-cell leukaemia/lymphoma https://www.sciencedirect.com/topics/medicine-and-dentistry/adult-t-cell-leukemia-lymphoma virus-I, which causes some distinctive forms of T-cell malignancy. The spectrum of peripheral T-cell NHL (PTCL) is as broad as that of B-cell neoplasms (seeTable 22.1) and histological features of clinically meaningful subtypes have proved difficult to define. Most are of CD4+ helper/inducer T-cell types but several CD8+ types are particularly associated with necrosis secondary to cytotoxic activity. Cont. in Part 2